Magnetic Resonance Signal Amplification by Reversible Exchange of Selective PyFALGEA Oligopeptide Ligands Towards Epidermal Growth Factor Receptors

The biorelevant PyFALGEA oligopeptide ligand, which is selective towards the epidermal growth factor receptor (EGFR), has been successfully employed as a substrate in magnetic resonance signal amplification by reversible exchange (SABRE) experiments. It is demonstrated that PyFALGEA and the iridium catalyst IMes form a PyFALGEA:IMes molecular complex. The interaction between PyFALGEA:IMes and H₂ results in a ternary SABRE complex. Selective 1D EXSY experiments reveal that this complex is labile, which is an essential condition for successful hyperpolarization by SABRE. Polarization transfer from parahydrogen to PyFALGEA is observed leading to significant enhancement of the ¹H NMR signals of PyFALGEA. Different iridium catalysts and peptides are inspected to discuss the influence of their molecular structures on the efficiency of hyperpolarization. It is observed that PyFALGEA oligopeptide hyperpolarization is more efficient when an iridium catalyst with a sterically less demanding NHC ligand system such as IMesBn is employed. Experiments with shorter analogues of PyFALGEA, that is, PyLGEA and PyEA, show that the bulky phenylalanine from the PyFALGEA oligopeptide causes steric hindrance in the SABRE complex, which hampers hyperpolarization with IMes. Finally, a single-scan ¹H NMR SABRE experiment of PyFALGEA with IMesBn revealed a unique pattern of NMR lines in the hydride region, which can be treated as a fingerprint of this important oligopeptide.     

Comprehensive numerical study of molecular diffusion effects and Eddy Dissipation Concept model in MILD combustion

Moderate or Intense Low-oxygen Dilution (MILD) combustion is a clean combustion technology with high thermal efficiency and low levels of emissions. In this paper, by employing Adelaide Jet-in-Hot-Co-flow (AJHC), several approaches are examined to increase the numerical solution accuracy. First, molecular diffusion effects are investigated in MILD combustion. Second, adjusting the Eddy Dissipation Concept (EDC) coefficients is comprehensively discussed, and finally, the reaction fraction coefficient and EDC formulation are investigated. The results show that the effect of enthalpy transport caused by molecular diffusion on the energy equation must be considered in the low oxygen concentration regions. Also, the maximum temperature in the MILD region can be kept constant by adjusting EDC coefficients. Furthermore, it is shown that applying the reaction fraction factor increases the accuracy of the numerical solution in the MILD region.     

煤巷高效快速掘进技术优化浅析

煤巷掘进效率低容易造成采掘接替紧张,以柠条塔煤矿S12002工作面胶运顺槽和辅运顺槽为工程背景,采用理论分析和现场工程对比试验相结合的方法,分析了制约巷道快速掘进各环节的因素,提出了优化控制对策。在减少顶板锚杆的支护数量,改良锚固方式并增大锚固长度和排距后,支护效率提高了20%,支护密度降低了30%,极大降低了顶板支护环节的时间;对掘进工艺进行优化后,将日单进水平从35 m左右提升到50~60 m左右,月单进水平从900 m提升到1500 m以上,创出了单日掘进75 m新水平,实现了高效快速掘进。实践表明,该方式现场成巷效果良好,可以满足煤巷高效快速掘进的需要。     

基于马尔可夫随机场的加密二值图像有损压缩算法

尽管当前已有众多二值图像的压缩方法,但这些方法并不能直接应用于加密二值图像的压缩。在云计算、分布式处理等场景下,如何高效地对加密二值图像进行有损压缩仍然是一个挑战,而当前鲜有这方面的研究。针对此问题,提出了一种基于马尔可夫随机场(MRF)的加密二值图像有损压缩算法。该算法用MRF表征二值图像的空域统计特性,进而借助MRF及解压缩还原的像素推断加密二值图像压缩过程中被丢弃的像素。所提算法的发送方采用流密码对二值图像进行加密,云端先后利用分块均匀但块内随机的下抽样方式及低密度奇偶校验(LDPC)编码对加密二值图像进行压缩,接收方则通过构造包含解码、解密及MRF重构的联合因子图实现二值图像的有损重构。实验结果表明,所提算法获得了较好的压缩效率,在0.2~0.4 bpp压缩率时有损重构图像的比特误差率(BER)不超过5%;而与针对未加密原始二值图像的国际压缩标准JBIG2的压缩效率相比,所提算法的压缩效率与其相当。这些充分表明了所提算法的可行性与有效性。     

杨木预水解液中化学组分质量浓度的P因子调控

为研究P因子对木质纤维原料预水解液中化学组分质量浓度的调控机制，分析了不同预水解温度（170~210℃）和预水解时间（30~120 min）条件下，杨木预水解液中固形物、木质素、木糖和葡萄糖质量浓度的变化规律。结果表明：升高预水解温度和延长预水解时间，固形物、木质素和葡萄糖质量浓度均逐渐增大。而木糖质量浓度随温度的升高而降低；190℃时，木糖质量浓度随预水解时间延长迅速减小。P因子对杨木预水解液中化学组分的质量浓度具有调控作用。固形物、木质素和葡萄糖质量浓度随P因子增加呈指数增大。而木糖质量浓度随P因子增加呈指数减小，P因子小于3 300时，木糖质量浓度随P因子增加迅速减小。     

里程计辅助的高精度车载GNSS/INS组合导航系统

针对城市隧道、偏远山区等复杂路况下,卫星导航系统信号被遮挡较严重或无卫星导航系统信号的场景中,车载GNSS/INS组合导航系统精度下降的问题,提出一种里程计辅助的高精度车载GNSS/INS组合导航方法。该方法中的组合滤波模式可根据载车环境变化在GNSS/INS组合模式和DR/INS组合模式间实现自适应切换,该组合导航方法将三维里程计航位推算位置误差作为状态量扩充到常规组合导航滤波器中,里程计的标度因数误差、安装角误差可通过里程计误差标定方法离线精确得到,后续使用只需将里程计误差参数装订到组合导航系统中即可。车载试验表明,7 km的信号遮挡场景下组合导航系统单个方向上的位置误差最大值也不大于8 m,整个跑车过程中位置误差在3 m以内,进一步保证了车载GNSS/INS组合导航系统复杂路况下的高精度定位。     

Electrocatalytic activity for the hydrogen evolution of the electrodeposited Co–Ni–Mo,Co–Ni and Co–Mo alloy coatings

The electrocatalytic activity for the HER of the ternary Co–Ni–Mo and the binary Co–Ni and Co–Mo alloy coatings is investigated in 1 M KOH solution. The surface morphology and the structure of the studied coatings is characterized by SEM and XRD analysis. The electrocatalytic activity for the HER is evaluated using cyclic voltammetry, electrochemical impedance spectroscopy, cathodic polarization and chronopotentiometry techniques. XRD analysis reveals that all studied coatings are composed of the Co hcp structure. However, alloy deposits with Mo is characterized by more nanocrystalline structure. Electrochemical experiments reveal superior electrocatalytic activity of coatings with Mo in comparison to Co–Ni alloy. This is the results of larger real surface area of Co–Mo and Co–Ni–Mo alloys, which is confirmed by the higher surface roughness factors (R_f) calculated based on the EIS results. The ternary alloy coating is characterized by the highest R_f parameter and the highest catalytic activity for the HER.     

Experimental analysis of combined side weir-gate located on a straight channel

Flow measurement and control in open channel system for lateral flow is important to support the system management. The flow characteristics of combined side weir-gate are complicated due to changes in flow conditions along the side weir-gate section. Experimental investigation of the flow characteristics of both weir and sluice gates is crucial for predicting the flow through a combined side weir-gate structure. Although weir-gate structures are widely used for frontal flow in hydraulic structures, the same is not true for lateral flows. In this study, 650 laboratory tests were conducted to determine the flow characteristics of combined side weir-gate for subcritical flow, and the experimental results were analyzed to determine the effect of these characteristics and weir-gate geometry on discharge capacity. Interaction factor of combined side weir-gate is a function of the upstream Froude number, the ratio of gate opening to upstream flow depth, the ratio of distance between the top of the sluice gate and the weir crest to gate opening, the ratio of weir and gate length to upstream flow depth, and the ratio of weir and gate length to main channel width. Consequently, more discharge is passed through combined side weir-gate compared to side weir and sluice gates. The empirically derived equations for the discharge of combined side weir-gate show good compatibility with the experimental data.     

Evaluation of back-calculated elastic moduli of unreinforced and geocell-reinforced unbound granular material from full-scale field tests

This paper presents a field-scale experimental track over a poor subgrade with an unreinforced section and a geocell-reinforced section subjected to in-situ performance tests. Plate load tests and Benkelman beam tests were carried out distributed in several unreinforced and reinforced layers. The objective was to: (1) examine the variability of the elastic modulus of unbound granular material (UGM) due the influence of its thickness and the presence of poor subgrade in its base, (2) evaluate the modulus improvement factor (MIF) generated by the geocell reinforcement in the UGM and (3) verify the most appropriate condition to apply the MIF to transport infrastructure design. The results showed that there is a significant influence of the thickness of the UGM layer on its elastic modulus when the layer is supported directly over a soft subgrade. The MIF values obtained in field suggest that its determination is mostly related to the UGM maximum elastic modulus rather than its decreased values (by virtue of poor subgrade or reduced thicknesses), and that the analytical formulation presented for MIF calculation has good predictive capability to be applied to pavement design.